Chemistry and Physics of Lipids

نویسندگان

  • Robert Engel
  • JaimeLee Iolani Rizzo
  • Diego Montenegro
  • Jay Leb
  • Delroy Coleman
  • Carolyn Hong
  • Herby Jeanty
  • Marie Thomas
چکیده

Herein is reported the preparation of several series of symmetrical polyammonium salts that serve as cationic lipids or precursors thereof, and are structurally based on several series of parent diamines where dimethylazonia functionalities are present, separated by a central structural unit, and pendant terminal chains. The resultant materials are of significant interest for a variety of purposes, such as serving as antihydrophobic species and as transfectins, the details of which are provided in separate reports. Attempts to effect selective alkylation to provide the corresponding unsymmetrical cationic lipids were without success, always leading to relatively useless mixtures of products. © 2009 Elsevier Ireland Ltd. All rights reserved.

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تاریخ انتشار 2009